| Annotated protein: | Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein) (RPIP1). Gene symbol: RGS14. Taxonomy: Mus musculus (Mouse). Uniprot ID: P97492 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RGS14 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Squires KE, et al. "Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain" Brain Struct Funct. 2018 Jan;223(1):233-253 PMID:28776200 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Loss of RGS14 allows for induction of nascent LTP in CA2 neurons following high-frequency stimulation that is blocked by a specific MEK inhibitor." - "However, CA2 neurons differ from their neighboring neurons by their curious lack of plasticity following synaptic stimulation to Schaffer collateral synapses (7). We discovered that the loss of RGS14 confers to CA2 neurons a robust capacity for this type of plasticity (Fig. 2C), whereas CA2 neurons from wild-type animals exhibited little LTP following HFS as expected. On the other hand, both the RGS14-KO and WT mice displayed normal LTP in CA1 neurons assessed in field potentials (Fig. 2E). The basal synaptic transmission in CA2 and CA1 neurons was also normal in both WT and KO animals (Fig. S3). Hence, RGS14 may act as a natural brake to limit synaptic plasticity within the CA2 following stimulation." - "We find that the MEK inhibitor U0126 completely prevented this robust LTP induction in CA2 neurons (Fig. 2D), thus implicating RGS14 as a suppressor of MAP kinase signaling in this process. The MEK inhibitor also blocked LTP in CA1 neurons (Fig. 2F), as expected (24), suggesting a key role for MEK/ERK signaling in the regulation of LTP in both CA2 and CA1 neurons." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2864 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |