Annotated protein:	Endophilin-B2 (SH3 domain-containing GRB2-like protein B2). Gene symbol: SH3GLB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5PPJ9
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SynGO gene info:	SynGO data @ SH3GLB2
Ontology domain:	Cellular Component
SynGO term:	postsynaptic endocytic zone (GO:0098843)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Loebrich S, et al. "CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors" Curr Biol. 2016 Feb 8;26(3):296-308 PMID:26776730
Figure(s):	Fig.3, 5
Annotation description:	Fig.3: "Endogenous CPG2 and Endogenous EndoB2 Co-localize and Bind Each Other at Synapses" - "Consistent with the role of both proteins in synaptic CME, endogenous EndoB2 and CPG2 co-localized in dendritic spines (Figure 3A)" Fig.5: "CPG2 and EndoB2 Co-localize and Recruit Components of the Endocytic Machinery to F-Actin" - "Triple labeling of V5-EndoB2, clathrin-GFP, and PSD95-tdTomato expressed in cultured neurons, revealed that EndoB2 and clathrin co-localize in the direct vicinity of the postsynaptic density (Figure 5A). Further, CPG2 was found to co-localize with endogenous clathrin in dendritic spines (Figure 5B). These results show that CPG2, clathrin heavy chain, and EndoB2 co-localize at the endocytic zone in postsynaptic compartments."
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Over-expression Antibody (detection)
Evidence tracking, Experiment Assay:	Wide-field fluorescence
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2862
Dataset release (version):	20231201
View annotation as GO-CAM model: