| Annotated protein: | AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein). Gene symbol: AP2M1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P84092 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP2M1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic neurotransmitter receptor endocytosis (GO:0098884) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Kastning K, et al. "Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2" Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2991-6 PMID:17289840 |
| Figure(s): | Fig.1, 3, 4, 5 |
| Annotation description: | Fig.1: "AMPA receptor CTs associate directly with AP2μ" Fig.3: "Direct high-affinity binding of μ2-adaptin to the GluR2 CT" Fig.4: "The GluR2-derived AP-2μ binding peptide targets a synaptotagmin 1 ΔC2B chimeric reporter protein for internalization" Fig.5: "The Syt-1 AP-2 binding peptide increases mEPSC amplitude and frequency" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2859 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |