| Annotated protein: | Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI). Gene symbol: PACSIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z0W5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PACSIN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density membrane (GO:0098839) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Perez-Otano I, et al. "Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1" Nat Neurosci. 2006 May;9(5):611-21 PMID:16617342 |
| Figure(s): | Fig.8 |
| Annotation description: | Fig.8: "Within dendritic spines, gold particles [for PACSIN1] were found at synaptic and perisynaptic sites, along the extrasynaptic plasma membrane, and associated with intracellular vesicles in lateral domains of the PSD (Fig. 8a). Double-labeling showed NR3A and PACSIN1 immunoparticles colocalizing at the same synaptic specialization (Fig. 8a)." Note: with perisynaptic the authors mean attached to the lateral side of the PSD. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2848 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |