| Annotated protein: | G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (Membrane estrogen receptor) (mER). Gene symbol: GPER1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BMP4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPER1 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Xu W, et al. "GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice" Neurobiol Learn Mem. 2018 Mar;149:10-19 PMID:29421611 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Effects of G1 on hippocampal synaptic plasticity" - "Although DHPG-LTD in SC-CA1 synapses was not affected in G1-treated slices (Fig. 4C), it was altered in MF-CA3 synapses after G1 treatment (Fig. 4D). The maintainace of LTD was prolonged after G1 treatment. In addition, MF-CA3 and SC-CA1 synapse inputs-outputs were not altered after G1 treatment (Fig. 4E and F). These data suggest that G1 facilitated DHPG-LTD in the CA3, which likely explains the memory enhancement by G1." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Similar findings in mouse hippocampus (EM-data) @ PMID:25673833 |
| SynGO annotation ID: | 2847 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |