| Annotated protein: | 14-3-3 protein zeta/delta (Mitochondrial import stimulation factor S1 subunit) (Protein kinase C inhibitor protein 1) (KCIP-1). Gene symbol: YWHAZ. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P63102 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ YWHAZ |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization (GO:0099572) |
| Annotated paper: | Couve A, et al. "Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins" Mol Cell Neurosci. 2001 Feb;17(2):317-28 PMID:11178869 |
| Figure(s): | fig.1, 4, 5 |
| Annotation description: | From results section: "...a large proportion of 14-3-3z was found in membrane associated fractions and revealed a pattern of distribution that closely resembled that of GABABR1a (Fig. 5, bottom panel, lanes 3-7). These patterns of distribution suggest an enrichment of GABABR1a and 14-3-3z in pre- and postsynaptic fractions." From fig 1: "GABABR1 associates with 14-3-3z in brain pull down assays." From fig 4: "GABABR1a colocalizes with 14-3-3z in a heterologous expression system and in hippocampal neurons." |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot IP + WB/MSMS Y2H |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2839 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |