Annotated protein:	Regulator of G-protein signaling 7-binding protein (R7 family-binding protein). Gene symbol: RGS7BP. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BQP9
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SynGO gene info:	SynGO data @ RGS7BP
Ontology domain:	Cellular Component
SynGO term:	presynapse (GO:0098793)
Synapse type(s):	cerebellum
Annotated paper:	Aguado C, et al. "Cellular and Subcellular Localization of the RGS7/Gbeta5/R7BP Complex in the Cerebellar Cortex" Front Neuroanat. 2016 Nov 30;10:114 PMID:27965545
Figure(s):	Fig.5
Annotation description:	Fig.5: "Subcellular localization of RGS7, Gβ5 and R7BP in PCs" - "Immunoparticles for R7BP were primarily detected at postsynaptic sites (89.7%; n = 3.266), with low labeling detected at presynaptic sites (10.3%; n = 377; Figures 5G,H). Postsynaptically, labeling for R7BP was mainly found associated with intracellular membranes at cytoplasmic sites in dendritic shafts and spines (72.1%; n = 2.628), with lower frequency along the plasma membrane (17.5%; n = 638; Figures 5G,H). Of the intracellular immunoparticles, most were found in dendritic shafts (66.7%; n = 2.431), and few of them in dendritic spines of PCs (5.4%; n = 197), as also happened for the R7BP immunoparticles along the plasma membrane (13.6%, n = 490 in dendritic shafts; and 4.1%; n = 148, in dendritic spines; Figures 5G,H).?
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2834
Dataset release (version):	20231201
View annotation as GO-CAM model: