| Annotated protein: | Calsyntenin-1 [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]. Gene symbol: CLSTN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6Q0N0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CLSTN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of spine apparatus membrane (GO:0099065) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Vogt L, et al. "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain" Mol Cell Neurosci. 2001 Jan;17(1):151-66 PMID:11161476 |
| Figure(s): | Fig.8 |
| Annotation description: | Fig.8: "Ultrastructural localization of the transmembrane fragment of proteolytically cleaved calsyntenin-1 over the spine apparatus of spine synapses" - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2827 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |