Annotated protein:	Calsyntenin-2. Gene symbol: CLSTN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9ER65
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SynGO gene info:	SynGO data @ CLSTN2
Ontology domain:	Cellular Component
SynGO term:	integral component of postsynaptic density membrane (GO:0099061)
Synapse type(s):	cerebellum, glutamatergic hippocampus, glutamatergic neocortex, glutamatergic
Annotated paper:	Hintsch G, et al. "The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns" Mol Cell Neurosci. 2002 Nov;21(3):393-409 PMID:12498782
Figure(s):	Fig.4
Annotation description:	Fig.4: "At the electron-microscopic level, immunoreactivity for both calsyntenin-2 and -3 was most prominent in the postsynaptic specializations of asymmetric (Type I) synapses with both axodendritic and axospinous localization (Figs. 4E-4G and 5E-5H). Sections through the proximal dendrites revealed also strong immunolabeling of some internal membraneous organelles (Fig. 4G). In sections through the neuronal somas, calsyntenin-2 and -3 immunoreactivity was also found on the membranes of the endoplasmic reticulum and the Golgi apparatus. Occasionally, patchy staining of the somal and dendritic plasmamembrane was found (not shown)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2825
Dataset release (version):	20231201
View annotation as GO-CAM model: