| Annotated protein: | Calsyntenin-3 (Cst-3) (Alcadein-beta). Gene symbol: CLSTN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99JH7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CLSTN3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | cerebellum, glutamatergic hippocampus, glutamatergic neocortex, glutamatergic |
| Annotated paper: | Hintsch G, et al. "The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns" Mol Cell Neurosci. 2002 Nov;21(3):393-409 PMID:12498782 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.5: "At the electron-microscopic level, immunoreactivity for both calsyntenin-2 and -3 was most prominent in the postsynaptic specializations of asymmetric (Type I) synapses with both axodendritic and axospinous localization (Figs. 4E-4G and 5E-5H). Sections through the proximal dendrites revealed also strong immunolabeling of some internal membraneous organelles (Fig. 4G). In sections through the neuronal somas, calsyntenin-2 and -3 immunoreactivity was also found on the membranes of the endoplasmic reticulum and the Golgi apparatus. Occasionally, patchy staining of the somal and dendritic plasmamembrane was found (not shown)." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2824 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |