| Annotated protein: | Calsyntenin-3 (Cst-3) (Alcadein-beta). Gene symbol: CLSTN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99JH7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CLSTN3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Um JW, et al. "Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins" Cell Rep. 2014 Mar 27;6(6):1096-1109 PMID:24613359 |
| Figure(s): | Fig.1, 4-6 |
| Annotation description: | Fig.3: "Expressions of CSTs in Mouse Brains" - "All three CST proteins were significantly expressed (although not clearly enriched) in the PSD fraction (Figure 3F), consistent with previously reported biochemical data (Vogt et al., 2001). Taken together, these results indicate that CST-3 is a PSD-localized synaptogenic adhesion molecule." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2822 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |