| Annotated protein: | Rho GTPase-activating protein 39. Gene symbol: ARHGAP39. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9C0H5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGAP39 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lim J, et al. "The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons" Curr Biol. 2014 Mar 31;24(7):786-92 PMID:24656827 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "CNK2 is Required for Dendritic Spine Morphogenesis" - "These defects appeared to be due to the specific loss in Vilse binding in that a similar increase in dendritic protrusions was observed in neurons overexpressing either GFP-VBR-CNK2 or GFP-WW-Vilse to disrupt the CNK2/Vilse interaction (Figure 3D,E). Overexpression of Vilse also had an effect on spine formation, with neurons expressing GFP-Vilse having smooth dendritc shafts and few if any spines or dendrites (Figure 3D,E), a phenotye similar to that reported for neurons expressing RacN17 [23]. " |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2817 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |