| Annotated protein: | Rho GTPase-activating protein 39 (Preoptic regulatory factor 2) (PORF-2). Gene symbol: ARHGAP39. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P18890 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGAP39 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lim J, et al. "The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons" Curr Biol. 2014 Mar 31;24(7):786-92 PMID:24656827 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3A: "CNK2 is Required for Dendritic Spine Morphogenesis" - "As previously reported [25], CNK2 was detected in the dendritic spines of primary hippocampal rat neurons cultured for 18 days in vitro (18 DIV), and it colocalized with the excitatory synaptic marker PSD95 (Figure 3A). Endogenous Vilse also colocalized with PSD95 (Figure 3A) and could be co-immunoprecipitated with CNK2 from lysates of 18 DIV neurons (Figure 3A), confirming the endogenous interaction of these proteins in hippocampal neurons." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2816 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |