| Annotated protein: | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1). Gene symbol: DVL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51141 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DVL1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ciani L, et al. "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II" Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10732-7 PMID:21670302 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Wnt7a acts through Dvl1 to regulate spine morphogenesis" - "To determine the downstream requirements for Wnt7a signaling in spines, the localization of Dvl1 was examined. Endogenous Dvl1 is present in the postsynaptic density (PSD) fraction (Fig. 2E) and at dendritic spines (Fig. 2F), suggesting that Wnt7a could regulate spine development by signaling directly via Dvl1 within dendritic spines." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2813 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |