| Annotated protein: | Protein Wnt-7a. Gene symbol: WNT7A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P24383 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WNT7A |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ciani L, et al. "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca(2)(+)/Calmodulin-dependent protein kinase II" Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10732-7 PMID:21670302 |
| Figure(s): | Fig.1-3 |
| Annotation description: | Fig.1: "Wnt7a specifically stimulates the formation and function of excitatory synapses" Fig.2: "Wnt7a acts through Dvl1 to regulate spine morphogenesis" Fig.3: "Wnt mutant mice exhibit defects in dendritic spine morphogenesis and excitatory synaptic function in the hippocampus" [Fig.6: "Wnt7a induces CaMKII phosphorylation and promotes CaMKII activity at spines."] |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Microscopy (generic) Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2812 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |