| Annotated protein: | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1). Gene symbol: DVL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51141 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DVL1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Ciani L, et al. "Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1" Nat Commun. 2015 Sep 24;6:8302 PMID:26400647 |
| Figure(s): | Fig.1, 3-8 |
| Annotation description: | Fig.1: "Wnt7a-Dvl1 signalling regulates release probability at glutamatergic synapses in the hippocampus" Fig.3: "Acute exposure to Wnt7a increases release probability without affecting synapse number in mature hippocampal neurons" Fig.4: "Wnt signalling regulates synaptic vesicle number". Fig.5: "Wnt signalling regulates the RRP size" Fig.6: "Wnt signalling regulates SNARE complex formation and Dvl1 interacts with proteins of the release machinery" Fig.7: "Wnts modulate the interaction between Dvl1 and Syt-1" Fig.8: "Binding between Dvl1 and Syt-1 is required for normal neurotransmitter release" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Electron Microscopy Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2808 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |