Annotated protein:Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1). Gene symbol: DVL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51141
antibody wiki:
SynGO gene info:SynGO data @ DVL1
Ontology domain:Biological Process
SynGO term:regulation of synaptic vesicle exocytosis (GO:2000300)
Synapse type(s):Schaffer collateral synapse (CA3->CA1)
Annotated paper:Ciani L, et al. "Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1" Nat Commun. 2015 Sep 24;6:8302 PMID:26400647
Figure(s):Fig.1, 3-8
Annotation description:Fig.1: "Wnt7a-Dvl1 signalling regulates release probability at glutamatergic synapses in the hippocampus"

Fig.3: "Acute exposure to Wnt7a increases release probability without affecting synapse number in mature hippocampal neurons"

Fig.4: "Wnt signalling regulates synaptic vesicle number".

Fig.5: "Wnt signalling regulates the RRP size"

Fig.6: "Wnt signalling regulates SNARE complex formation and Dvl1 interacts with proteins of the release machinery"

Fig.7: "Wnts modulate the interaction between Dvl1 and Syt-1"

Fig.8: "Binding between Dvl1 and Syt-1 is required for normal neurotransmitter release"
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Over-expression
Evidence tracking, Experiment Assay:Electron Microscopy
Whole-cell patch clamp
IP + WB/MSMS
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2808
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology