| Annotated protein: | Protein Wnt-3a. Gene symbol: WNT3A. Taxonomy: Homo sapiens (Human). Uniprot ID: P56704 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WNT3A |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Davis EK, et al. "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation" Neural Dev. 2008 Nov 5;3:32 PMID:18986540 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Wnt proteins that activate β-catenin signaling increase presynaptic inputs" - "Application of Wnt3a, Wnt7a, or Wnt7b increased the number of excitatory presynaptic puncta (Figure 6A-F), suggesting that canonical Wnt signaling positively influences synapse formation." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2798 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |