| Annotated protein: | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3). Gene symbol: DVL3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q61062 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DVL3 |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chen J, et al. "Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation" J Biol Chem. 2006 Apr 28;281(17):11910-6 PMID:16501258 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "Distribution of Wnt signaling proteins in the mouse hippocampus" - "Puncta of Wnt3a and Frizzled-4 signals showed extensive co-localizations with PSD-95 (Fig. 1, b-d and f-h), indicating their localization at the synaptic regions. As Frizzled-4 physically interacts with PSD-95 (39), this Wnt receptor is most likely localized on the post-synaptic membrane. Dishevelled-3 puncta overlapped with PSD-95 to a lesser extent (Fig. 1, j-l), whereas β-catenin displayed a more diffused pattern with signal clusters (Fig. 1, n-p), which is consistent with previous studies (40). These results suggest that Wnt signaling operates at hippocampal synapses." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2797 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |