Annotated protein: | Protein Wnt-3a. Gene symbol: WNT3A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P27467 |
antibody wiki: | |
SynGO gene info: | SynGO data @ WNT3A |
Ontology domain: | Cellular Component |
SynGO term: | synapse (GO:0045202) |
Synapse type(s): | hippocampus, glutamatergic |
Annotated paper: | Chen J, et al. "Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation" J Biol Chem. 2006 Apr 28;281(17):11910-6 PMID:16501258 |
Figure(s): | Fig.1 |
Annotation description: | Fig.1: "Distribution of Wnt signaling proteins in the mouse hippocampus" - "Puncta of Wnt3a and Frizzled-4 signals showed extensive co-localizations with PSD-95 (Fig. 1, b-d and f-h), indicating their localization at the synaptic regions. As Frizzled-4 physically interacts with PSD-95 (39), this Wnt receptor is most likely localized on the post-synaptic membrane. Dishevelled-3 puncta overlapped with PSD-95 to a lesser extent (Fig. 1, j-l), whereas β-catenin displayed a more diffused pattern with signal clusters (Fig. 1, n-p), which is consistent with previous studies (40). These results suggest that Wnt signaling operates at hippocampal synapses." |
Evidence tracking, Biological System: | Intact tissue |
Evidence tracking, Protein Targeting: | Antibody (detection) |
Evidence tracking, Experiment Assay: | Confocal |
Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
SynGO annotation ID: | 2795 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |