Annotated protein:Protein Wnt-3a. Gene symbol: WNT3A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P27467
antibody wiki:
SynGO gene info:SynGO data @ WNT3A
Ontology domain:Cellular Component
SynGO term:synapse (GO:0045202)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Chen J, et al. "Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation" J Biol Chem. 2006 Apr 28;281(17):11910-6 PMID:16501258
Figure(s):Fig.1
Annotation description:Fig.1: "Distribution of Wnt signaling proteins in the mouse hippocampus"
- "Puncta of Wnt3a and Frizzled-4 signals showed extensive co-localizations with PSD-95 (Fig. 1, b-d and f-h), indicating their localization at the synaptic regions. As Frizzled-4 physically interacts with PSD-95 (39), this Wnt receptor is most likely localized on the post-synaptic membrane. Dishevelled-3 puncta overlapped with PSD-95 to a lesser extent (Fig. 1, j-l), whereas β-catenin displayed a more diffused pattern with signal clusters (Fig. 1, n-p), which is consistent with previous studies (40). These results suggest that Wnt signaling operates at hippocampal synapses."
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2795
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology