| Annotated protein: | FERM and PDZ domain containing 4. Gene symbol: FRMPD4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A3K7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FRMPD4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lee HW, et al. "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis" J Neurosci. 2008 Dec 31;28(53):14546-56 PMID:19118189 |
| Figure(s): | Fig.1, 2 |
| Annotation description: | Fig.1: "Interaction between PSD-95 and Preso" - "These results suggest that PSD-95 promotes synaptic localization of Preso through their PDZ interaction." Fig.2: "Expression patterns of Preso mRNAs and proteins" - "Preso proteins were detected in various subcellular fractions of rat brain, including crude synaptosomes (P2), cytosol (S3), and light membranes (P3) (Fig. 2H). The upper, but not the lower, Preso band was enriched in postsynaptic density (PSD) fractions including the PSD III fraction (Fig. 2I), indicative of a very tight association with the PSD." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Electrophysiology (generic) IP + WB/MSMS Y2H |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2786 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |