| Annotated protein: | Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]. Gene symbol: NRG1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6DR98 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRG1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse to nucleus signaling pathway (GO:0099527) |
| Synapse type(s): | cochlea, glutamatergic |
| Annotated paper: | Bao J, et al. "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos" Nat Neurosci. 2004 Nov;7(11):1250-8 PMID:15494726 |
| Figure(s): | Fig.1, 2, 5 |
| Annotation description: | Fig.1: "Upregulation of PSD-95 and nuclear Nrg-ICD after synaptic activation" Fig.2: "Activation of PSD-95 promoter by the Nrg-ICD and Eos complex on Ikaros sites" Fig.5: "Synaptic activity-dependent activation of PSD-95 promoter by Nrg-ICD" Note: neuregulin-1 levels increase in the nucleus. The orgin of neuregulin-1 is not shown but inferred from the known postsynaptic expression of in the postsynaptic neuron ("the presynaptic cells, the inner and outer hair cells, express ErbB2 and ErbB4 receptors25,27, whereas the postsynaptic neurons, spiral ganglion neurons (SGNs), express Nrg-1 abundantly18,28.") and the relation to the synaptic stimulation. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal ChIP |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2775 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |