| Annotated protein: | Neurocan core protein (Chondroitin sulfate proteoglycan 3). Gene symbol: NCAN. Taxonomy: Mus musculus (Mouse). Uniprot ID: P55066 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCAN |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhou XH, et al. "Neurocan is dispensable for brain development" Mol Cell Biol. 2001 Sep;21(17):5970-8 PMID:11486035 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Electrophysiological characterization of neurocan-deficient mice" - "No significant differences were detectable in basic synaptic transmission, e.g., input-output curve and paired-pulse facilitation (data not shown). In contrast, maintenance of LTP was disturbed to some extent. While tetanic stimulation of CA1 pyramidal cells induced a rapid and profound synaptic potentiation in slices from homozygous neurocan-deficient mice, which did not significantly differ from that of wild-type controls, the potentiation decayed more rapidly in knockout animals than in wild-type animals (Fig. (Fig.6A).6A)" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) none of the above |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 2772 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |