| Annotated protein: | Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]. Gene symbol: CLSTN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9EPL2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CLSTN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endosome (GO:0098845) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Ster J, et al. "Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development" J Neurosci. 2014 Jun 25;34(26):8716-27 PMID:24966372 |
| Figure(s): | Fig.5 |
| Annotation description: | Figure 5: "Calsyntenin-1 colocalizes with dendritic endosomes that transport NMDA receptor subunits" - "the considerable degree of colocalization of dendritic calsyntenin-1 puncta with both the transferrin receptor (TfR), a marker for recycling endosomes, as well as with APP, which is carried in early endosomal calsyntenin-1 vesicles (Steuble et al., 2012), indicates that dendritic calsyntenin-1-associated vesicles are involved in transport of both early and recycling endosomal organelles (Fig. 5A,B). Importantly, dendritic calsyntenin-1 also colocalizes with NMDA receptor subunits (Fig. 5C,D)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2760 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |