Annotated protein:Neuroligin-1 (Neuroligin I). Gene symbol: NLGN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62765
antibody wiki:
SynGO gene info:SynGO data @ NLGN1
Ontology domain:Biological Process
SynGO term:regulation of presynapse organization (GO:0099174)
Synapse type(s):pons
cerebellum
Annotated paper:Scheiffele P, et al. "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons" Cell. 2000 Jun 9;101(6):657-69 PMID:10892652
Figure(s):Fig.2, 3, 4, 7
Annotation description:Postsynaptic NLGN1; neuroligin 1 is a regulator of presynaptic assembly via presynaptic beta-neurexin.

Fig.2: "Neuroligin Expression in HEK293 Cells Causes Accumulation of Synapsin in Axons"
Fig.3: "Synaptic Vesicles Undergo Turnover at Contacts Formed with Neuroligin-Transfected HEK293 Cells"
Fig.4: "Neuroligin-Expressing Cells Induce the Formation of Presynaptic Structures"
Fig.7: "Soluble β-Neurexin Reduces Granule Cell-Induced Clustering of Synapsin in Pontine Axons"
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Antagonist / agonist
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2756
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology