Annotated protein:	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3). Gene symbol: MDGA1. Taxonomy: Homo sapiens (Human). Uniprot ID: Q8NFP4
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SynGO gene info:	SynGO data @ MDGA1
Ontology domain:	Biological Process
SynGO term:	regulation of presynapse assembly (GO:1905606)
Synapse type(s):	hippocampus, GABAergic
Annotated paper:	Gangwar SP, et al. "Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges" Neuron. 2017 Jun 21;94(6):1132-1141.e4 PMID:28641112
Figure(s):	Fig.1, 3, 4, 5
Annotation description:	Fig.1: "Analysis of MDGA1-NL interaction using cell-surface binding assays" Fig.3: "MDGA knockdown increases inhibitory synapse density in an NL2-dependent manner in cultured neurons" Fig.4: "MDGA1 overexpression decreases inhibitory, but not excitatory, synaptic transmission in cultured cortical neurons" Fig.5: "MDGA1 cis expression inhibits NL2 activity in artificial synapse-formation assays and cell-adhesion assays" Coclusion: MDGA1 is a cis-interactor with NL2 and negatively affects its transsynaptic adhesion to neurexin and its ability to induce presynapse assembly.
Evidence tracking, Biological System:	Cultured neurons Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal Whole-cell patch clamp
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Additional literature:	See also Fig.3+4 @ PMID:23358245
SynGO annotation ID:	2751
Dataset release (version):	20231201
View annotation as GO-CAM model: