| Annotated protein: | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein). Gene symbol: SNAP25. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P60881 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SNAP25 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle exocytosis (GO:0016079) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Blasi J, et al. "Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25" Nature. 1993 Sep 9;365(6442):160-3 PMID:8103915 |
| Figure(s): | Fig.1, Fig.2 |
| Annotation description: | Botulinum neurotoxin A selectively cleaves the SNARE protein SNAP-25 when incubated with isolated synaptic membranes. Resulting in inhibition of neurotransmitter release. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) Enzyme assay |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 275 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |