| Annotated protein: | Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CS84 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Taniguchi H, et al. "Silencing of neuroligin function by postsynaptic neurexins" J Neurosci. 2007 Mar 14;27(11):2815-24 PMID:17360903 |
| Figure(s): | Fig.3, 4, 5, 6 |
| Annotation description: | Background: this paper reports on the non-conventional role of postsynaptic Nrxn1; neurexin 1 beta in negatively regulating the ability to induce presynaptic differentiation of neuroligin 1. Fig.3: "cis-expression of neurexins reduces synaptogenic activity of neuroligin-1 in hippocampal neurons" Fig.4: "cis-expressed neurexins directly block synaptogenic activity of neuroligin-1" Fig.5: "β-Neurexin overexpression results in upregulation of neuroligins in cis" Fig.6: "Dendritic neurexin expression reduces vGlut1 clustering and neurexin binding in dissociated hippocampal neurons" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2749 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |