| Annotated protein: | Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha). Gene symbol: NRXN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63372 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN1 |
| Ontology domain: | Biological Process |
| SynGO term: | presynapse assembly (GO:0099054) |
| Synapse type(s): | hippocampus cerebellum |
| Annotated paper: | Dean C, et al. "Neurexin mediates the assembly of presynaptic terminals" Nat Neurosci. 2003 Jul;6(7):708-16 PMID:12796785 |
| Figure(s): | Fig.5, 6, 7 |
| Annotation description: | Rationale: NLGN1; neuroligin 1 is a postsynaptic protein. Neurexin-1beta is a presynaptic protein (Fig.4, 6, 7). These proteins are shown to mediate cell-cell adhesion (Fig.2). Together this means that these proteins are involved in 'synapse adhesion between pre- and post-synapse (GO:0099560)'. The relevance of this interaction is shown in the ability of these two protein to be able to induce pre- and postsynaptic differentiation (Fig.6, 7 and ticket #2745). Fig.5: "Overexpression of neuroligin-1 induces recruitment of neurexin to newly forming synapses" Fig.6: "Induction of neurexin clustering and presynaptic differentiation by purified neuroligin" Fig.7: "Clustering of neurexin is sufficient to induce recruitment of synaptic vesicles" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2748 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |