| Annotated protein: | Neuroligin-2. Gene symbol: NLGN2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q62888 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NLGN2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | pons cerebellum |
| Annotated paper: | Scheiffele P, et al. "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons" Cell. 2000 Jun 9;101(6):657-69 PMID:10892652 |
| Figure(s): | Fig.2, 5 |
| Annotation description: | Postsynaptic NLGN2; neuroligin 2 is a regulator of presynaptic assembly via presynaptic beta-neurexin. Fig.2: "Neuroligin Expression in HEK293 Cells Causes Accumulation of Synapsin in Axons" - "...when HEK293 cells were transfected with a construct encoding epitope-tagged neuroligin-1 ab or neuroligin-2, dramatic accumulations of synapsin were observed (Figure 2 2D-2I)." Fig.5: "Overexpression of Adhesion Molecules Is Not Sufficient to Induce Synaptic Vesicle Clustering in Pontine Axons" - " |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2745 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |