| Annotated protein: | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) (mBLVR1). Gene symbol: AP3D1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O54774 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP3D1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | striatum |
| Annotated paper: | Newell-Litwa K, et al. "Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus" J Neurosci. 2010 Jan 20;30(3):820-31 PMID:20089890 |
| Figure(s): | fig. 3F, 4 |
| Annotation description: | The authors used an antibody against AP-3 delta for immunofluorescence and immuno EM. The specificity of the antibody was confirmed using an AP-3 delta knockout mouse. Fig.3F: "AP-3 also labels a dendritic spine in the striatum (F)" Note: localization to postsynapse does not represent the majority of AP-3 delta in the synapse (Fig.4). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Peter McPherson (ORCID:0000-0001-7806-5662) |
| Lab: | Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada |
| SynGO annotation ID: | 2742 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |