| Annotated protein: | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2). Gene symbol: PPFIA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BSS9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPFIA2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytosol (GO:0099523) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wong MY, et al. "Liprin-alpha3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses" Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2234-2239 PMID:29439199 |
| Figure(s): | Fig 1, 5 |
| Annotation description: | Wong et.al. use STED microscopy to demonstrate that Liprin a2 (gene product of PPFIA2) is localized in the presynaptic terminal. Diffuse signal was observed throughout the terminal. In a separate experiment, knockout of the close homolog Liprin a3 led to a striking recruitment of Liprin a2 to the presynaptic active zone. This suggest that Liprin a2 may have a role at the active zone as well. Specificity of the antibody for Liprin a2 was previously determined by Zurner et.al. 2011. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Zurner et.al. provides characterization of the liprin a2 antibody. @ PMID:21618221 |
| SynGO annotation ID: | 2735 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |