| Annotated protein: | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP). Gene symbol: ASAP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9QWY8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ASAP1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jain S, et al. "Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development" PLoS One. 2012;7(9):e46340 PMID:23050017 |
| Figure(s): | Fig.10 |
| Annotation description: | Figure 10: "ASAP1, an Arf4 GAP, inhibits dendritic spine formation, and both Arf4-WT and Arf4-Q71L partially rescue this inhibition." 20/01/2021 Dnyanada: ASAP1 is a regulator of the actin cytoskeleton (PMID: 10725410). Overexpression of ASAP1-Flag shows a significant decrease in total spine density which is rescued by overexpression of Arf4 indicating that Arf4 and ASAP1 might interact to influence spine cytoskeletal dynamics. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2712 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |