| Annotated protein: | ADP-ribosylation factor 4. Gene symbol: ARF4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P61750 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARF4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jain S, et al. "Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development" PLoS One. 2012;7(9):e46340 PMID:23050017 |
| Figure(s): | Fig.5, 6, 7, 8, 9, 12 |
| Annotation description: | Fig.5: "Decreased dendritic spine density and mEPSC amplitude in the DG of Arf4+/- mice compared to WT mice." Fig.6: "Expression of Arf4 in brain of 4.5-month-old mice and in primary neurons, and the effect of Arf4 overexpression on dendritic morphology." Fig.7: "Arf4 overexpression promotes dendritic spine development in mouse primary neurons." Fig.8: "Overexpression of constitutively active Arf4 (Arf4-Q71L) promotes dendritic spine development to a greater extent that Arf4-WT." Fig.9: "Knockdown of Arf4 by shRNA reduces spine density in mouse primary neurons." Fig.12: "Arf4 overexpression rescues spine loss in apoE4-expressing primary neurons." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2711 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |