| Annotated protein: | SLIT and NTRK-like family, member 3. Gene symbol: SLITRK3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A062 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLITRK3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | brain |
| Annotated paper: | Yim YS, et al. "Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases" Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4057-62 PMID:23345436 |
| Figure(s): | fig 1E |
| Annotation description: | SLITRK3 was enriched in PSD fractions up to PSDIII. 23/2/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | A majority of YFP-Slitrk3 puncta colocalized well with clusters of the inhibitory postsynaptic scaffold gephyrin apposed to VGAT (Fig. 2a) and with GABA receptor γ2 clusters apposed to VGAT (Fig. 2b), but hardly colocalized with the excitatory postsynaptic scaffold PSD-95 or VGLUT1 (Fig. 2c,d). The presence of YFP-Slitrk3 puncta in dendrites, but not axons, of transfected neurons revealed postsynaptic, but not presynaptic, accumulation (Supplementary Fig. 3). @ PMID:22286174 |
| SynGO annotation ID: | 2700 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |