| Annotated protein: | Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Stargazin) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2). Gene symbol: CACNG2. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88602 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CACNG2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic neurotransmitter receptor diffusion trapping (GO:0098970) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Bats C, et al. "The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking" Neuron. 2007 Mar 1;53(5):719-34 PMID:17329211 |
| Figure(s): | Fig.2, 3, 4, 6, 7, 8 |
| Annotation description: | Fig.2: "Stargazin ΔC Reduces Hippocampal Excitatory Synaptic Currents" Fig.3: "Overexpression of Stargazin ΔC::GFP Increases the Mobility of GluR1 and GluR2 Subunits in Neuronal Membrane" Fig.4: "Stargazin Is Involved in AMPAR Stabilization at Synaptic Sites" Fig.6: "Stargazin Stabilizes AMPAR in Neuronal Membrane through Its Specific Interaction with PSD-95" Fig.7: "Stargazin Diffusion Is Reduced on PSD-95 Clusters" Fig.8: "Stargazin and AMPARs Diffuse as Complexes in the Synaptic and Extrasynaptic Membrane" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Whole-cell patch clamp |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| SynGO annotation ID: | 2697 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |