| Annotated protein: | Crk-like protein. Gene symbol: CRKL. Taxonomy: Mus musculus (Mouse). Uniprot ID: P47941 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CRKL |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of postsynaptic membrane (GO:0098890) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Hallock PT, et al. "Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L" Genes Dev. 2010 Nov 1;24(21):2451-61 PMID:21041412 |
| Figure(s): | Fig 6, Fig s4 |
| Annotation description: | Researchers found an enrichment of Crk-L in mouse adult and developing neuromuscular synapses by performing immunostaining using an antibody against Crk-L. Staining was found in synapses identified using alpha-Bungarotoxin-594 to label AChRs. Imaging was performed using confocal microscopy. 10/4/2017 Pim: - "extrinsic component..." selected because the paper shows recruitment of Crk-L to the plasma membrane via interaction with another protein. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 268 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |