| Annotated protein: | Glypican 4. Gene symbol: GPC4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q642B0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPC4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Synapse type(s): | retina, glutamatergic hippocampus, glutamatergic |
| Annotated paper: | Allen NJ, et al. "Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors" Nature. 2012 May 27;486(7403):410-4 PMID:22722203 |
| Figure(s): | Fig.2-4 |
| Annotation description: | GPC4 is sufficient to increase surface clustering of GluA1 AMPA receptors and to induce structural synapse formation. 21/2/2018 Pim - GPC6 is a protein secreted by astrocytes, but also seems anchored to the presynaptic membrane (see ticket #2208). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2679 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |