| Annotated protein: | Tyrosine-protein kinase (EC 2.7.10.2). Gene symbol: ABL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: E9PT20 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABL1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic specialization assembly (GO:0099150) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Perez de Arce K, et al. "Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation" J Neurosci. 2010 Mar 10;30(10):3728-38 PMID:20220006 |
| Figure(s): | Fig.2, 3, 5, 6 |
| Annotation description: | Fig.2: "c-Abl modulates the synaptic contact number and PSD-95 clustering" - "These results suggest that c-Abl activity specifically modulates PSD-95 clustering and not the general structure of the postsynaptic compartment." Fig.3: "c-Abl kinase activity modulates synaptic clustering of PSD-95" - "Altogether, these results demonstrate that c-Abl activity is required for PSD-95 clustering." Fig.4: "c-Abl interacts with PSD-95, and STI571 modulates PSD-95 tyrosine phosphorylation in hippocampal culture" Fig.5: "PSD-95 tyrosine phosphorylation is regulated by c-Abl activity" - "these results indicate that GST-PSD-95 can be tyrosine phosphorylated by c-Abl." Fig.6: "Tyrosine 533 residue of PSD-95 is phosphorylated by c-Abl and is relevant for PSD-95 clustering" - "These results indicate that the regulation of PSD-95 clustering by c-Abl is mediated by Y533 phosphorylation." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2677 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |