| Annotated protein: | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG). Gene symbol: ABL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q4JIM5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABL2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lin YC, et al. "Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways" J Neurosci. 2013 Jan 30;33(5):1846-57 PMID:23365224 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "Arg is localized and enriched at dendritic spines" - "Arg-RFP was selectively enriched in >90% of dendritic spines, while co-expressed green fluorescent protein (GFP) was found at comparable levels in both dendritic spines and dendrite shafts (Fig. 1A, B)." - "Although Arg-RFP localizes predominantly to the post-synaptic compartment, shown by its colocalization with the postsynaptic marker PSD-95 (Fig. 1F), residual levels of Arg have also been localized to presynaptic terminals (Moresco et al., 2003; Sfakianos et al., 2007)" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2675 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |