Annotated protein:Synaptopodin. Gene symbol: SYNPO. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CC35
antibody wiki:
SynGO gene info:SynGO data @ SYNPO
Ontology domain:Biological Process
SynGO term:regulation of postsynaptic cytosolic calcium levels (GO:0099566)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Korkotian E, et al. "Synaptopodin regulates spine plasticity: mediation by calcium stores" J Neurosci. 2014 Aug 27;34(35):11641-51 PMID:25164660
Figure(s):Fig. 1, 2, 6, 7, 8, 9
Annotation description:Regulation of Ca++ stores in spines.
And in turn regulation of morphological and functional spine plasticity.
"The mechanism through which SP may promote plasticity is indicated by the observations that STIM-1, the sensor of calcium concentration in stores, and Orai-1, the calcium-induced calcium entry channel, are colocalized with SP, in the same dendritic spines."
Comparison of WT and SP-KO mice.
Figure 6. Ca++ transients in response to photolysis of caged glutamate are larger in synaptopodin-containing spines regardless of spine shape

17/3/2017 Pim
Fig.1/2: SP-KO results in changed synaptic transmission
Fig.6: Ca++ transients in response to photolysis of caged glutamate are larger in synaptopodin-containing spines regardless of spine shape
Fig.7: intracellular Ca-stores are responsible
Fig.8/9: SER is involved since STIM1 and Orai1 move into spines.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Electrophysiology (generic)
Optical physiology
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:267
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology