| Annotated protein: | Synaptopodin. Gene symbol: SYNPO. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CC35 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNPO |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic cytosolic calcium levels (GO:0099566) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Korkotian E, et al. "Synaptopodin regulates spine plasticity: mediation by calcium stores" J Neurosci. 2014 Aug 27;34(35):11641-51 PMID:25164660 |
| Figure(s): | Fig. 1, 2, 6, 7, 8, 9 |
| Annotation description: | Regulation of Ca++ stores in spines. And in turn regulation of morphological and functional spine plasticity. "The mechanism through which SP may promote plasticity is indicated by the observations that STIM-1, the sensor of calcium concentration in stores, and Orai-1, the calcium-induced calcium entry channel, are colocalized with SP, in the same dendritic spines." Comparison of WT and SP-KO mice. Figure 6. Ca++ transients in response to photolysis of caged glutamate are larger in synaptopodin-containing spines regardless of spine shape 17/3/2017 Pim Fig.1/2: SP-KO results in changed synaptic transmission Fig.6: Ca++ transients in response to photolysis of caged glutamate are larger in synaptopodin-containing spines regardless of spine shape Fig.7: intracellular Ca-stores are responsible Fig.8/9: SER is involved since STIM1 and Orai1 move into spines. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Electrophysiology (generic) Optical physiology |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 267 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |