| Annotated protein: | Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI). Gene symbol: PACSIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z0W5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PACSIN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Perez-Otano I, et al. "Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1" Nat Neurosci. 2006 May;9(5):611-21 PMID:16617342 |
| Figure(s): | Fig.5, 6, 7, 8 |
| Annotation description: | Fig.5: "NR3A binds the neuron-specific endocytic adaptor PACSIN1/syndapin1" Fig.6: "PACSIN1 mediates NR3A endocytosis" Fig.7: "PACSIN1 reduces the functional surface expression of NR3A-containing triheteromeric NMDARs" Fig.8: "PACSIN1 mediates synaptic removal of NR3A" Note: with perisynaptic the authors mean attached to the lateral side of the PSD. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal IP + WB/MSMS Y2H |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2660 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |