| Annotated protein: | Synaptopodin. Gene symbol: SYNPO. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CC35 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNPO |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Deller T, et al. "Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity" Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10494-9 PMID:12928494 |
| Figure(s): | Fig. 4 |
| Annotation description: | knock-out of synaptopodin affects synaptic transmission. Fig. 4: Reduced hippocampal LTP Field excitatory postsynaptic potentials (fEPSP) measured in the CA1 stratum radiatum were evoked by stimulation of the Schaffer collateral commissural afferents in KO animals. 14/3/2017 Pim - The postsynaptic element of the annotation comes from the exclusive localization of SYNPO at the postsynaptic spine apparatus. Interfering with SYNPO expression is therefore inferred to regulate synaptic transmission via a postsynaptic mechanism (also spine apparatus is missing here). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings Electrophysiology (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 266 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |