| Annotated protein: | Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C). Gene symbol: GRIN2C. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q01098 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN2C |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Kadotani H, et al. "Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit" J Neurosci. 1996 Dec 15;16(24):7859-67 PMID:8987814 |
| Figure(s): | Fig.3, 4 |
| Annotation description: | Fig.3: "Spontaneous mossy fiber-granule cell EPSCs" - "The current-voltage plots of the magnitude of the fast component (peak amplitude of the fast component) were linear in all four genotypes, consistent with the properties of non-NMDA receptor responses. In contrast, the amplitude of the slow component (10 msec after the peak of the fast component) was reduced at hyperpolarized potentials in both the wild-type and NR2A-/- mutant mice (Fig. 3 B). This reduction was more marked in the NR2C-/- mutant mice, and the slow component nearly disappeared in the NR2A-/-/NR2C-/- mutant mice (Fig.3 B). " Fig.4: "Granule cell EPSCs elicited by mossy fiber stimulation" - "The decay time, however, was slightly slower in the NR2A-/- mutant mice than in the wild-type mice and was faster in the NR2C-/- mutant mice (Table 1)" Abstract: "The NR2A and NR2C subunits thus contribute to distinct NMDA receptor-mediated excitatory transmission in mossy fiber-granule cell synapses in the mature cerebellum" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2653 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |