| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (PTPNU-3) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Mus musculus (Mouse). Uniprot ID: B0V2N1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Horn KE, et al. "Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity" J Neurochem. 2012 Jul;122(1):147-61 PMID:22519304 |
| Figure(s): | fig 7 |
| Annotation description: | Fig.7: Reduced hippocampal long-term potentiation in PTPRS null mice. 2/3/2018 Pim - The whole story in this paper is on a role of PTPRS in synapse formation and presynaptic differentiation. The effect on LTP is treated as a somewhat separate issue by the authors. I aprove of a separate anntotation to term 'modulation of chemical synaptic transmission (GO:0050804)' for this reason: "In contrast, we found that RPTPσ null mice perform better than wild-type littermates in a novel object recognition test. Interestingly, RPTPδ knockout mice also exhibit a reciprocal disconnection between learning and synaptic plasticity: while Schaffer collateral-CA1 LTP was enhanced in RPTPδ null mice, they have deficits in spatial learning and memory tasks (Uetani et al. 2000). These findings reveal that both RPTPσ and RPTPδ contribute to synaptic plasticity and learning and memory, and provide examples in which the ability to induce LTP is not positively correlated with learning and memory capacity. Importantly, this difference between RPTPσ and RPTPδ reveals a previously unappreciated level of functional diversity between members of the type IIa LAR subfamily of tyrosine phosphatases at synapses." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2650 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |