Annotated protein:	Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2). Gene symbol: GABRA2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P23576
antibody wiki:	search antibodypedia...
SynGO gene info:	SynGO data @ GABRA2
Ontology domain:	Cellular Component
SynGO term:	integral component of postsynaptic specialization membrane (GO:0099060)
Synapse type(s):	hippocampus, GABAergic
Annotated paper:	Nusser Z, et al. "Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells" Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11939-44 PMID:8876241
Figure(s):	Fig.2
Annotation description:	Fig.2: "GABAA receptors in synaptic junctions on somata" - "synapses immunoreactive for the a2 subunit was highest on AISs (Fig.2A and B). Only a fraction of symmetrical synapses on somata, proximal, and distal dendrites showed immunoreactivity for the a2 subunit (Fig. 2C). Immunopositive synapses were also present on the somato-dendritic domain of a subset of GABAergic interneurons in all layers (not shown)." Abstract: ". The al subunit has been found in most GABAergic synapses on all postsynaptic domains of pyramidal cells. In contrast, the a2 subunit was located only in a subset of synapses on the somata and dendrites, but in most synapses on axon initial segments innervated by axo-axonic cells."
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2649
Dataset release (version):	20231201
View annotation as GO-CAM model: