| Annotated protein: | Synaptopodin. Gene symbol: SYNPO. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z327 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNPO |
| Ontology domain: | Cellular Component |
| SynGO term: | spine apparatus (GO:0097444) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Deller T, et al. "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons" J Comp Neurol. 2000 Mar 6;418(2):164-81 PMID:10701442 |
| Figure(s): | Fig. 6c-e, Fig. 5-9 |
| Annotation description: | Figure 6 c-e: Immunogold localization of synaptopdin to the spine apparatus of synapses in the in stratum radiatum of the hippocampal CA3 region Figs. 5-9. Localization of the immunoperoxidase reaction product at spine apparatuses of various hippocampal synapses. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol. 1997 Oct 6;139(1):193-204. Cloning of original cDNA Figure 6: EM localization (DAB) to dendritic spines in telencephalon Highly concentrated at the PSD, but extension of IR into dendritic shaft. @ PMID:9314539 Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Stefani GG, Zuniga A, Schwarz K, Bonhoeffer T, Zeller R, Frotscher M, Mundel P. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10494-9 Fig. 3 a,b Immunogold localization @ PMID:12928494 |
| SynGO annotation ID: | 264 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |