Annotated protein:	Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22). Gene symbol: ABHD17A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5XIJ5
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SynGO gene info:	SynGO data @ ABHD17A
Ontology domain:	Biological Process
SynGO term:	regulation of postsynapse organization (GO:0099175)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Yokoi N, et al. "Identification of PSD-95 Depalmitoylating Enzymes" J Neurosci. 2016 Jun 15;36(24):6431-44 PMID:27307232
Figure(s):	Fig.8
Annotation description:	Fig.8; "ABHD17 specifically mediates PSD-95 depalmitoylation in neurons. " - "When we simultaneously knocked-down ABHD17A, 17B, and 17C by the AAV-miRNA vector (Fig. 3E), ... Importantly, triple-knockdown of ABHD17 members apparently delayed PSD-95 depalmitoylation process (Fig. 8A, B) and significantly prolonged the half-life of palmitate on PSD-95 to 4.8 ± 1.3 h (Fig. 8D). When neurons were treated with 2-BP for 2 h, the intensity of synaptic PSD-95 clusters was significantly reduced (Fig. 8E,F), indicating rapid depalmitoylation of PSD-95 at local synapses. Consistent with biochemical data, this reduction of PSD-95 clusters was significantly suppressed in neurons in which ABHD17 members were knocked-down. " Fig.3: ABHD17A is also present in the PSD-95 fraction.
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	RNAi / shRNA
Evidence tracking, Experiment Assay:	Confocal Western blot
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2633
Dataset release (version):	20231201
View annotation as GO-CAM model: