| Annotated protein: | Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22). Gene symbol: ABHD17B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6AY17 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABHD17B |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of postsynaptic recycling endosome membrane (GO:0099033) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yokoi N, et al. "Identification of PSD-95 Depalmitoylating Enzymes" J Neurosci. 2016 Jun 15;36(24):6431-44 PMID:27307232 |
| Figure(s): | Fig.3D |
| Annotation description: | Figure 3: "Subcellular distribution of ABHD17" Fig.3D: "ABHD17 proteins show a very similar distribution pattern to TfR, which was colocalized with ABHD17 on the recycling endosomes (Fig. 3B,D) and is recycled between the cytoplasm and plasma membrane in the dendritic spine (Kennedy et al., 2010)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | The ABHD17 proteins are targeted to membranes by a palmitoylated N-terminal cysteine cluster. This membrane targeting is essential for their enzymatic activity. @ PMID:19092927 |
| SynGO annotation ID: | 2629 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |