| Annotated protein: | Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22). Gene symbol: ABHD17A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5XIJ5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABHD17A |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of postsynaptic recycling endosome membrane (GO:0099033) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Yokoi N, et al. "Identification of PSD-95 Depalmitoylating Enzymes" J Neurosci. 2016 Jun 15;36(24):6431-44 PMID:27307232 |
| Figure(s): | Fig.3B |
| Annotation description: | Figure 3: "Subcellular distribution of ABHD17" - "FLAG-tagged ABHD17A localized at the plasma membrane, and some populations were distributed in the dendrites as vesicular-like structures and partly colocalized with postsynaptic scaffolding protein Shank in dendritic spines (Fig. 3A)." - "We then examined the ABHD17A localization using various marker proteins and found that ABHD17A localized mainly on TfR-positive recycling endosomes in the dendritic shafts and spines (Fig. 3B)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | The ABHD17 proteins are targeted to membranes by a palmitoylated N-terminal cysteine cluster. This membrane targeting is essential for their enzymatic activity. @ PMID:19092927 |
| SynGO annotation ID: | 2622 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |