| Annotated protein: | SLIT and NTRK-like protein 3. Gene symbol: SLITRK3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q810B9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLITRK3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Takahashi H, et al. "Selective control of inhibitory synapse development by Slitrk3-PTPdelta trans-synaptic interaction" Nat Neurosci. 2012 Jan 29;15(3):389-98, S1-2 PMID:22286174 |
| Figure(s): | Fig.1, 3, 4, 5 |
| Annotation description: | Figure 1: "Slitrk3 selectively induces functional inhibitory presynaptic differentiation in coculture" Fig.3: "Slitrk3 knockdown decreases the density of inhibitory synapses in hippocampal culture" Fig.4: "Slitrk3-/- mice have reduced inhibitory synapse density in CA1 region of hippocampus" Fig.5: "Slitrk3-/- mice have reduced inhibitory synaptic transmission in CA1 of the hippocampus" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2621 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |